The Apothecary Diaries: Asami Seto on Shisui’s Ending and Voice Acting Insights at AX 2025

Key Facts

• The Apothecary Diaries Season 2 concluded on July 4.
• A continuation of the anime has been officially announced.
• Aoi Yuki and Asami Seto appeared at Anime Expo 2025.
• Seto revealed she prepared early for Shisui’s final scene in Episode 45.
• Yuki shared Seto’s behind-the-scenes “last date” comment from Episode 41.

At Anime Expo 2025 on July 4, The Apothecary Diaries hosted a guest panel featuring Aoi Yuki (Maomao) and Asami Seto (Loulan/Shisui), following the Season 2 finale and announcement of a sequel. During the event, the voice actors performed a key scene from Episode 45 and revealed behind-the-scenes details, including Seto’s early emotional preparation for Shisui’s final moments.

Live Voice Acting of Episode 45

The panel showcased live dubbing performances by Aoi Yuki and Asami Seto, with a special focus on scenes between Maomao and Shisui. Among them was the climactic moment in Episode 45, where Maomao hesitates between calling the character “Shisui” or “Loulan.” The scene was met with intense audience engagement, culminating in loud applause and a standing ovation.

The powerful delivery of this emotional exchange stirred the audience, and both the fans and moderator were visibly moved. The moment marked one of the highlights of the panel.

Asami Seto on Preparing for Shisui’s Final Scene

When asked about the scene's preparation, Asami Seto explained, “I already knew the ending from the beginning, so I kept it in mind while acting. I also referred to the manga while preparing. The final monologue by Loulan had a lot of lines, but it was a very important scene, so I started preparing well in advance.”

Aoi Yuki then revealed a private exchange from the recording of Episode 41, “The Fox Village,” recalling, “I said to Seto-chan, ‘Today’s a date episode!’ and she replied, ‘It’s the last date, isn’t it…’” The comment surprised the audience, causing a stir in the venue.

Seto added, “As Shisui, I had already accepted what was coming. So I was already feeling nervous before others.” Her remarks offered insight into the emotional weight she carried during the recording process.

Maomao and Shisui’s Perspectives Compared

Yuki also reflected on how the two characters perceived the same events differently. “From Maomao’s point of view, she’s just excited to visit a new village and learn about its culture. But from Shisui’s perspective, the same events feel entirely different,” she said. “There are a lot of subtle hints like that, so I hope fans rewatch the scenes with that in mind.”

The panel offered a rare look into the character work and preparation behind The Apothecary Diaries, showing how deeply the voice actors engage with their roles. With the announcement of a continuation, anticipation continues to grow for the series’ future.

The anime is based on the novel by Natsu Hyuuga and illustrated by Touko Shino, following Maomao—a pharmacist’s daughter obsessed with poisons—and the mysterious eunuch Jinshi, as they unravel complex cases in the imperial palace.

The Apothecary Diaries anime Trailer

FAQ

Q: What did Asami Seto say about preparing for Episode 45?
A: She knew the ending from the start and began preparing early, using the manga as a reference.

Q: What behind-the-scenes moment did Aoi Yuki share?
A: Yuki said that during Episode 41's recording, Seto called it “the last date,” referring to Shisui’s approaching farewell.

Q: What scene did they perform at AX 2025?
A: The voice actors performed the emotional scene from Episode 45 where Maomao decides how to address Shisui.

Q: How did the audience react to the performance?
A: The scene received a standing ovation and left both fans and the moderator visibly emotional.

Q: Has The Apothecary Diaries been confirmed for continuation?
A: Yes, a sequel was officially announced following the Season 2 finale.

Source : ORICON NEWS