The Apothecary Diaries: Episode 45 Voice Acting Secrets Shared at AX 2025

Key Facts

• The Apothecary Diaries Season 2 concluded on July 4.
• A continuation of the anime has been confirmed.
• Aoi Yuki and Asami Seto performed Episode 45 live at Anime Expo 2025.
• The scene involved Maomao choosing how to address Shisui.
• The performance was done without prior coordination between the voice actors.

On July 4, The Apothecary Diaries hosted a special guest panel at Anime Expo 2025 in Los Angeles, following the Season 2 finale and confirmation of a sequel. Voice actors Aoi Yuki and Asami Seto performed a live dubbing of Episode 45, a fan-favorite scene, and revealed that it was recorded without prior rehearsal—yet delivered with strong mutual understanding.

Emotional Episode 45 Scene Performed Live

During the The Apothecary Diaries panel at Anime Expo 2025, Aoi Yuki (Maomao) and Asami Seto (Loulan/Shisui) performed live dubbing of several scenes, with a strong audience response. Among them was Episode 45, “The Toad Tray,” which included a moment of emotional tension where Maomao decides whether to address the other character as “Shisui” or “Loulan.”

As the scene played out, the audience watched attentively. When the line was delivered, the crowd reacted with a powerful ovation. The performance prompted a standing ovation, and both fans and the moderator were visibly moved, with some wiping away tears as the panel continued.

Behind-the-Scenes of the Performance

When asked about how the scene was created, Asami Seto said, “I remember being very focused in front of the microphone during that recording session.” Aoi Yuki added, “We didn’t have any specific planning or coordination for this scene. We simply connected with each other, and the emotions naturally came through in the dialogue. It really felt like we were immersed in the roles.”

Seto went on to say, “For scenes like this, the actors’ focus is crucial. I was grateful for the environment that allowed us to record in such a concentrated way.” She also shared that after the recording, Yuki played a central role in maintaining a relaxed atmosphere in the studio.

Continued Support and Impact of the Series

The event followed the broadcast of Season 2’s final episode and the announcement of a continuation. With its North American fanbase showing strong support, the panel emphasized the international appeal of The Apothecary Diaries.

The anime, based on the original work by Natsu Hyuuga and illustrated by Touko Shino, follows Maomao—a pharmacist’s daughter with a deep interest in poisons and medicines—as she teams up with the enigmatic eunuch Jinshi to solve mysteries in the imperial court. The Episode 45 performance highlighted the series’ emotional depth and the strong chemistry between the voice cast.

The Apothecary Diaries anime Trailer

FAQ

Q: What scene from Episode 45 was performed at Anime Expo 2025?
A: The scene where Maomao chooses whether to call the other character “Shisui” or “Loulan” was performed live on stage.

Q: Did Aoi Yuki and Asami Seto rehearse the Episode 45 scene?
A: No, they did not rehearse it in detail, but connected naturally during the performance.

Q: What was the audience reaction during the panel?
A: The performance of Episode 45 received a standing ovation, with fans and the moderator visibly emotional.

Q: What did Aoi Yuki say about the dubbing session?
A: She said they didn't coordinate beforehand but emotionally aligned during the scene, feeling immersed in their roles.

Q: Has a sequel to The Apothecary Diaries been announced?
A: Yes, a continuation of the anime was confirmed at the event.

Source : ORICON NEWS